Enantioseparation by Dual-flow Countercurrent Extraction: Its Application to the Enantioseparation of (.+-.)-Propranolol.
نویسندگان
چکیده
منابع مشابه
Development of a new method based on chiral ligand-exchange chromatography for the enantioseparation of propranolol
A new chromatographic procedure was proposed for the separation of propranolol (PRN) enantiomers based upon enantioselective chiral ligand-exchange chromatography. The separation was carried out on a short C8 column leading to considerably short separation time. L-alanine and Cu2+ were applied as chiral selector and central bivalent complexing ion, respectively. It was found that the kind of co...
متن کاملDevelopment of a new method based on chiral ligand-exchange chromatography for the enantioseparation of propranolol
A new chromatographic procedure was proposed for the separation of propranolol (PRN) enantiomers based upon enantioselective chiral ligand-exchange chromatography. The separation was carried out on a short C8 column leading to considerably short separation time. L-alanine and Cu2+ were applied as chiral selector and central bivalent complexing ion, respectively. It was found that the kind of co...
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Microchip electrophoresis (MCE) has been recognized as an important separation technique on the research field of micro total analytical systems (μ-TAS) since the first publication on MCE was reported by Manz et al. in 1992 [1]. In MCE, there are several advantages, e.g., high speed analysis in seconds, small amount of sample, high separation efficiency, and high-throughput analysis by using mi...
متن کاملDevelopment of a New Method Based on Chiral Ligand-Exchange Chromatography for the Enantioseparation of Propranolol
A new chromatographic procedure was proposed for the separation of propranolol (PRN) enantiomers based upon enantioselective chiral ligand-exchange chromatography. The separation was carried out on a short C8 column leading to considerably short separation time. L-alanine and Cu2+ were applied as chiral selector and central bivalent complexing ion, respectively. It was found that the kind of co...
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In chiral and non-chiral electrophoretic resolution of basic drugs, adsorption of analytes to negatively charged capillary wall could lead to poor repeatability of migration time and peak area. In addition, chiral resolutions of basic drugs are commonly performed in low pH buffers. Therefore, longer analysis time due to suppression of electroosmotic flow (EOF) is another dilemma. In this wor...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1996
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.44.1521